Scientist, Neurotoxin & Biologics Process Sciences
Company: AbbVie
Location: Irvine
Posted on: May 16, 2022
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Job Description:
Scientist, Molecular Biology and Fermentation, Irvine,
California Research & Development Job Description About AbbVie
AbbVie (NYSE: ABBV) is a global, research-driven biopharmaceutical
company committed to developing innovative advanced therapies for
some of the world's most complex and critical conditions. The
company's mission is to use its expertise, dedicated people and
unique approach to innovation to markedly improve treatments across
four primary therapeutic areas: immunology, oncology, virology and
neuroscience. In more than 75 countries, AbbVie employees are
working every day to advance health solutions for people around the
world. For more information about AbbVie, please visit us at .
Follow on Twitter, Facebook or LinkedIn . Envision working with
energetic colleagues and inspirational leaders. Now, place yourself
in that mix; leading discussions, asking the right questions and
driving results. What Your New Manager Wants You To Know The
Scientist, Molecular Biology and Fermentation will be an
instrumental team member of the Neurotoxin & Biologics Process
Sciences Department, based in Irvine, CA. The primary role of the
scientist is to lead molecular biology activities including
expression vector construction, cell line engineering and genetic
verification of products for the use in bacterial biologics
development. The scientist will need to design and execute studies
for the evaluation of vector types/designs, promoters, strain
optimization, gene expression, genome manipulation (deletions and
knockout) in wild type bacteria and strategies for the evaluation
of novel recombinant proteins with the intent to optimize product
titer while minimizing process related impurities. Additional
experience in microbial physiology and mapping metabolism pathways
would be preferred. This role will include cell banking strategies
for research and early development studies and will continue to
support cell banks through tech transfer and used in clinical
trials as a subject matter expert. Experience with genetic
sequencing would be considered a plus. Additional responsibilities
include data analysis, troubleshooting process and equipment,
participation in project teams, lab inventory and organization,
maintaining detailed records of batches and experiments. The
secondary role of the scientist is to independently plan, design
studies using Design of Experiment (DOE) strategies, execute
experiments and develop processes to support the fermentation of
natural and recombinant proteins from bacterial cell cultures. The
scientist will support studies at small and intermediate scale
during various stages of development including process
characterization. The fermentation scientist will independently
operate shake flask and small-scale upstream equipment (Ambr - 250,
Biostat - B-DCU, single use fermenters, etc.). An ideal candidate
would have the ability to work as an integral part of an upstream
team and supporting drug discovery and downstream teams as well as
demonstrate a high degree of flexibility, creativity, and
initiative applied to the various duties and aspects of position.
Furthermore, the position requires the individual to work with
regulated Select Agents and Toxins access (i.e., Biosafety level 2
and biosafety level 3 laboratories). Access to and use of select
agents is regulated by federal policies. Therefore, the candidate
must conduct all work activities in compliance with AbbVie internal
and applicable regulatory requirements including health screening
and background checks. AbbVie internal requirements include
compliance with ethics, environmental health and safety, financial,
human resources, and general business policies, requirements, and
objectives. YOU ARE more than just a title, YOU ARE--- A strategic
thinker: align and excite internal stakeholders to facilitate
success through strong leadership, strategic thinking and personal
drive. First class team player: collaborate across multiple
disciplines to ensure compliance and ability to influence
cross-functional teams and senior leadership. You Will
Keywords: AbbVie, Irvine , Scientist, Neurotoxin & Biologics Process Sciences, Other , Irvine, California
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